Regulation of autophagy by ROS: physiology and pathology.

  title={Regulation of autophagy by ROS: physiology and pathology.},
  author={Ruth Scherz-Shouval and Zvulun Elazar},
  journal={Trends in biochemical sciences},
  volume={36 1},
Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize proteins, lipids and DNA. When tightly controlled, ROS serve as signaling molecules by modulating the activity of the oxidized targets. Accumulating data point to an essential role for ROS in the activation of autophagy. Be the outcome of autophagy survival or death and the initiation conditions starvation, pathogens or death receptors, ROS are invariably involved. The nature of this involvement, however… CONTINUE READING
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