Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species.

@article{DjavaheriMergny2007RegulationOA,
  title={Regulation of autophagy by NFkappaB transcription factor and reactives oxygen species.},
  author={Mojgan Djavaheri-Mergny and Manuella Amelotti and Julie Mathieu and Françoise Besançon and Chantal Bauvy and Patrice Codogno},
  journal={Autophagy},
  year={2007},
  volume={3 4},
  pages={
          390-2
        }
}
The NF-kappaB transcription factor is an important anti-apoptotic factor, which is frequently deregulated in cancer cells. We have recently demonstrated that NF-kappaB activation mediates the repression of autophagy in response to TNFa in three models of cancer cell lines. In contrast, in the absence of NF-kappaB activation, TNFa induces macroautophagy (autophagy), which requires reactive oxygen species (ROS) production and participates in the TNFalpha-induced apoptotic signaling pathway… CONTINUE READING

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