Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

@inproceedings{Milan2015RegulationOA,
  title={Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy},
  author={Giulia Milan and Vanina Romanello and Francesca Pescatore and Andrea Armani and Ji-Hye Paik and Laura Frasson and Anke Seydel and Jinghui Zhao and Reimar Abraham and Alfred L Goldberg and Bert Blaauw and Ronald A. Depinho and Marco Sandri},
  booktitle={Nature communications},
  year={2015}
}
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis. These conditions activate the family of Forkhead Box (Fox) O transcription factors. Here we report that muscle-specific deletion of FoxO members protects from muscle loss as a result of the role of FoxOs in the induction of autophagy-lysosome and ubiquitin-proteasome… CONTINUE READING
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