Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g.

@article{Ding2013RegulationOA,
  title={Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g.},
  author={Zufeng Ding and Xianwei Wang and Laura Schnackenberg and Magomed Khaidakov and Shijie Liu and Sandeep Kumar Singla and Yao Dai and Jawahar Lal Mehta},
  journal={International journal of cardiology},
  year={2013},
  volume={168 2},
  pages={1378-85}
}
OBJECTIVES Regulation of autophagy and apoptosis during treatment of vascular smooth muscle cells (VSMCs) with pro-atherogenic stimuli, such as oxidized low density lipoprotein (ox-LDL), remains unclear. METHODS AND RESULTS We examined the expression of autophagy and apoptosis upon treatment of VSMCs with ox-LDL. Exposure to ox-LDL in modest amounts (10-40 μg/ml) enhanced autophagy (expression of beclin-1, LC3-II/LC3-1 ratio and Atg5) and apoptosis (expression of caspase-3, Bax, Bcl-2 and Bcl… CONTINUE READING

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Pretreatment of VSMCs with the miRNA hsa - let-7 g inhibited autophagy , as LOX-1 expression and apoptosis declined .
Regulation of autophagy and apoptosis in response to ox - LDL in vascular smooth muscle cells , and the modulatory effects of the microRNA hsa - let-7 g. OBJECTIVES .
Pretreatment of VSMCs with the miRNA hsa - let-7 g inhibited autophagy , as LOX-1 expression and apoptosis declined .
Regulation of autophagy and apoptosis in response to ox - LDL in vascular smooth muscle cells , and the modulatory effects of the microRNA hsa - let-7 g. OBJECTIVES .
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