Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy

Abstract

Effective vaccination against tumour-associated antigens (TAA) such as the 5T4 oncofoetal glycoprotein may be limited by the nature of the T cell repertoire and the influence of immunomodulatory factors in particular T regulatory cells (Treg). Here, we identified mouse 5T4-specific T cell epitopes using a 5T4 knock out (5T4KO) mouse and evaluated… (More)
DOI: 10.1007/s00262-011-1167-3

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@article{Castro2011RegulationOA, title={Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy}, author={Fernanda V. Castro and Mariam Al-Muftah and Kate Mulryan and H Jiang and Jan-Wouter Drijfhout and Sumia Ali and Andrzej Rutkowski and Milena Kalaitsidou and David Edward Gilham and Peter Stern}, journal={Cancer Immunology, Immunotherapy}, year={2011}, volume={61}, pages={1005-1018} }