Regulation of autoantibody responses to glomerular basement membrane in man and experimental animals.


Autoantibodies reacting with the glomerular basement membrane (GBM) are a rare cause of severe nephritis in man. Their development is HLA-DR-associated and their pathogenicity has been demonstrated by transfer experiments. Their production is spontaneously self-limiting over a period of years but irreversible renal failure usually occurs within weeks or… (More)


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