Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease


The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies and triggered the clinical onset of autoimmune arthritis. By… (More)
DOI: 10.1038/ni.3579


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