Regulation of attention and response to therapy in dementia by butyrylcholinesterase.

  title={Regulation of attention and response to therapy in dementia by butyrylcholinesterase.},
  author={Kirsty K O'Brien and Brian K Saxby and Clive G. Ballard and J. C. Grace and Frances Harrington and Gary A. Ford and John T. O'Brien and Alan G Swan and Andrew F Fairbairn and Keith Wesnes and Teodoro del Ser and James A. Edwardson and Christopher M Morris and Ian G. McKeith},
  volume={13 4},
OBJECTIVES To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and the influence of butyrylcholinesterase on cognition. Acetylcholine plays a key role in attention and memory and reduced cortical acetylcholine is associated with the severity of dementia. Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood. METHODS We examined the… CONTINUE READING

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