Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.

@article{Metz2015RegulationOA,
  title={Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.},
  author={Patrick J. Metz and Janilyn Arsenio and Boyko Kakaradov and Stephanie H Kim and Kelly A Remedios and Katherine Elizabeth Oakley and Kazunori Akimoto and Shigeo Ohno and Gene W. Yeo and John T. Chang},
  journal={Journal of immunology},
  year={2015},
  volume={194 5},
  pages={
          2249-59
        }
}
During an immune response against a microbial pathogen, activated naive T lymphocytes give rise to effector cells that provide acute host defense and memory cells that provide long-lived immunity. It has been shown that T lymphocytes can undergo asymmetric division, enabling the daughter cells to inherit unequal amounts of fate-determining proteins and thereby acquire distinct fates from their inception. In this study, we show that the absence of the atypical protein kinase C (PKC) isoforms… CONTINUE READING
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