Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1.

@article{Waak2009RegulationOA,
  title={Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1.},
  author={Jens Waak and Stephanie S. Weber and Andrea Waldenmaier and Karin G{\"o}rner and Marianna Alunni-Fabbroni and Heinrich Schell and Daniela Maria Vogt-Weisenhorn and T. Pham and Veerle Reumers and Veerle Baekelandt and Wolfgang Wurst and Philipp J Kahle},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 8},
  pages={
          2478-89
        }
}
The Parkinson's disease (PD)-associated gene DJ-1 mediates direct neuroprotection. The up-regulation of DJ-1 in reactive astrocytes also suggests a role in glia. Here we show that DJ-1 regulates proinflammatory responses in mouse astrocyte-rich primary cultures. When treated with a Toll-like receptor 4 agonist, the bacterial endotoxin lipopolysaccharide (LPS), Dj-1-knockout astrocytes generated >10 times more nitric oxide (NO) than littermate controls. Lentiviral reintroduction of DJ-1 restored… CONTINUE READING
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