Regulation of arylamine N-acetyltransferases.

@article{Butcher2008RegulationOA,
  title={Regulation of arylamine N-acetyltransferases.},
  author={Neville J Butcher and Jacky M Tiang and Rodney F. Minchin},
  journal={Current drug metabolism},
  year={2008},
  volume={9 6},
  pages={
          498-504
        }
}
Acetylation catalysed by the arylamine N-acetyltransferases (NATs; 2.3.1.5) is a major biotransformation pathway for arylamine and hydrazine drugs, as well as many carcinogens that we are exposed to on a daily basis. These compounds can either be detoxified by NATs or bioactivated to metabolites that have the potential to cause toxicity such as cancer. As a result, the levels of NATs in the body have clinical importance with regard to drug effect and individual susceptibility to toxicity. Like… CONTINUE READING

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