Regulation of arthritis by p53: critical role of adaptive immunity.

@article{imelyte2005RegulationOA,
  title={Regulation of arthritis by p53: critical role of adaptive immunity.},
  author={Egle {\vS}imelyte and Sanna Rosengren and David L. Boyle and Maripat Corr and Douglas R Green and Gary S. Firestein},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 6},
  pages={1876-84}
}
OBJECTIVE The p53 tumor-suppressor protein is expressed in rheumatoid arthritis synovium, and loss of p53 function through somatic mutation can occur in longstanding disease. Previous studies demonstrated that p53 is protective in murine collagen-induced arthritis (CIA). To determine if adaptive immune responses or synovial effector functions are responsible for this effect, passive models of arthritis were studied in p53 wild-type and knockout mice. METHODS Models of passive CIA, passive K… CONTINUE READING

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