Regulation of arrestin binding by rhodopsin phosphorylation level.

  title={Regulation of arrestin binding by rhodopsin phosphorylation level.},
  author={Sergey A. Vishnivetskiy and Dayanidhi Raman and Junhua Wei and Matthew J Kennedy and James B Hurley and Vsevolod V. Gurevich},
  journal={The Journal of biological chemistry},
  volume={282 44},
Arrestins ensure the timely termination of receptor signaling. The role of rhodopsin phosphorylation in visual arrestin binding was established more than 20 years ago, but the effects of the number of receptor-attached phosphates on this interaction remain controversial. Here we use purified rhodopsin fractions with carefully quantified content of individual phosphorylated rhodopsin species to elucidate the impact of phosphorylation level on arrestin interaction with three biologically relevant… CONTINUE READING

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