Regulation of arachidonic acid release and cytosolic phospholipase A2 activation.

  title={Regulation of arachidonic acid release and cytosolic phospholipase A2 activation.},
  author={Miguel A. Gij{\'o}n and Christina C. Leslie},
  journal={Journal of leukocyte biology},
  volume={65 3},
The 85-kDa cytosolic PLA2 (cPLA2) mediates agonist-induced arachidonic acid release in many cell models, including mouse peritoneal macrophages. cPLA2 is regulated by an increase in intracellular calcium, which binds to an amino-terminal C2 domain and induces its translocation to the nuclear envelope and endoplasmic reticulum. Phosphorylation of cPLA2 on S505 by mitogen-activated protein kinases (MAPK) also contributes to activation. In macrophages, zymosan induces a transient increase in… CONTINUE READING
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The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages

  • Qiu, Z.-H, M. A. Gijón, M. S. de Carvalho, D. M. Spencer, C. C. Leslie
  • J. Biol
  • 1998
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