Regulation of arachidonic acid metabolism in macrophages by immune and nonimmune interferons.

@article{Boraschi1985RegulationOA,
  title={Regulation of arachidonic acid metabolism in macrophages by immune and nonimmune interferons.},
  author={Diana Boraschi and Stefano Censini and M Bartalini and Aldo Tagliabue},
  journal={Journal of immunology},
  year={1985},
  volume={135 1},
  pages={502-5}
}
Mouse resident peritoneal M phi release AAA and metabolize it into cyclooxygenase- and lipoxygenase-derived eicosanoids, when triggered in vitro with different stimuli. Pretreatment of M phi with nonimmune IFN-alpha and IFN-beta dramatically decreased AA liberation from M phi phospholipids and eicosanoid formation after stimulation of M phi with Zy, A23187, or PMA. M phi exposed to immune IFN-gamma also showed a substantial impairment of both AA liberation and eicosanoid production upon… CONTINUE READING
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