Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

@article{Singh2018RegulationOA,
  title={Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins},
  author={Rumani Singh and Anthony Letai and Kristopher Sarosiek},
  journal={Nature Reviews Molecular Cell Biology},
  year={2018},
  volume={20},
  pages={175-193}
}
The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including neurological and infectious diseases as well as environmental and medical toxicities. Conversely, the abnormal survival and accumulation of damaged or superfluous cells drive prominent human pathologies such as cancers and autoimmune diseases. Apoptosis is an evolutionarily conserved cell death pathway that is responsible for the programmed culling… CONTINUE READING
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