Regulation of apoptosis by ubiquitination.

@article{Lee2003RegulationOA,
  title={Regulation of apoptosis by ubiquitination.},
  author={Justine C Lee and Marcus E Peter},
  journal={Immunological reviews},
  year={2003},
  volume={193},
  pages={
          39-47
        }
}
Cell elimination through apoptosis, or programmed cell death, is an evolutionarily conserved central tenet of biology from embryological development to immune homeostasis. While many of the apoptotic signaling pathways have been elucidated, the relationship between ubiquitin and apoptosis is only beginning to be defined. In the past decade, many reports of polyubiquitin conjugation of key pro- and anti-apoptotic molecules have characterized ubiquitin as an essential regulatory modification… CONTINUE READING
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