Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes.

@article{Wei2005RegulationOA,
  title={Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes.},
  author={Li Fei Wei and Xinghua Hou and Kazuhiko Tatemoto},
  journal={Regulatory peptides},
  year={2005},
  volume={132 1-3},
  pages={27-32}
}
The novel 36-amino acid peptide, apelin, is the endogenous ligand for the orphan receptor APJ. Apelin may play important roles in the regulation of the cardiovascular system and the hypothalamic-pituitary axis. It is a potent hypotensive agent and one of the most potent stimulators of cardiac contractility. In this study, we investigated the roles of apelin derived from adipocytes in the regulation of cardiovascular homeostasis. We found that both apelin and APJ mRNAs were expressed in isolated… CONTINUE READING

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