Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.

@article{Osipovich2010RegulationOA,
  title={Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.},
  author={Oleg Osipovich and Eugene M. Oltz},
  journal={Seminars in immunology},
  year={2010},
  volume={22 6},
  pages={313-22}
}
Many aspects of gene function are coordinated by changes in the epigenome, which include dynamic revisions of chromatin modifications, genome packaging, subnuclear localization, and chromosome conformation. All of these mechanisms are used by developing lymphocytes to regulate the assembly of functional antigen receptor genes by V(D)J recombination. This… CONTINUE READING