Regulation of anterior pituitary gonadotropin subunit mRNA levels during the preovulatory gonadotropin surge: A physiological role of progesterone in regulating LH-β and FSH-β mRNA levels

@article{Brann1993RegulationOA,
  title={Regulation of anterior pituitary gonadotropin subunit mRNA levels during the preovulatory gonadotropin surge: A physiological role of progesterone in regulating LH-$\beta$ and FSH-$\beta$ mRNA levels},
  author={Darrell W. Brann and James L. O'Conner and Marlene F. Wade and Pedro L. Zamorano and Virendra B. Mahesh},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1993},
  volume={46},
  pages={427-437}
}
  • D. Brann, J. O'Conner, +2 authors V. Mahesh
  • Published 1 October 1993
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
In a previous study we demonstrated that in the ovariectomized estrogen-primed immature rat, progesterone induced a gonadotropin surge while the gonadotropin mRNA subunit levels were either suppressed or unaltered. This observation has now been confirmed using more frequent time points. Progesterone administered at 0900 h was found to suppress LH-beta mRNA levels at 1300, 1400, and 0800 h the next day, with no subsequent effects at 1000, 1200 or 1600 h. FSH-beta mRNA levels were unaffected by… Expand
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Progesterone-induced surges of LH and FSH appear to require an intact N-methyl-D-aspartate (NMDA) neurotransmission line, since administration of the NMDA receptor antagonist, MK801, blocked the ability of progesterone to induce LH andFSH surges. Expand
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TLDR
It is suggested that the depletion of cytosol estradiol receptors of the anterior pituitary/hypothalamic unit may be causally related to the preovulatory gonadotropin surge resulting from PMSG administration to immature female rats. Expand
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