Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

@article{Mcpherron1999RegulationOA,
  title={Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11},
  author={Alexandra C. Mcpherron and Ann M. Lawler and Se-Jin Lee},
  journal={Nature Genetics},
  year={1999},
  volume={22},
  pages={260-264}
}
The bones that comprise the axial skeleton have distinct morphological features characteristic of their positions along the anterior/posterior axis. We previously described a novel TGF-β family member, myostatin (encoded by the gene Mstn, formerly Gdf8), that has an essential role in regulating skeletal muscle mass. We also identified a gene related to Mstn by low-stringency screening. While the work described here was being completed, the cloning of this gene, designated Gdf11 (also called… 
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