Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathway.

@article{Kijima1996RegulationOA,
  title={Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathway.},
  author={Kazuhisa Kijima and Hiroaki Matsubara and Satoshi Murasawa and Kayo Maruyama and Naohiko Ohkubo and Yasukiyo Mori and Mitsuo Inada},
  journal={Hypertension},
  year={1996},
  volume={27 3 Pt 2},
  pages={529-34}
}
In the present study, rat angiotensin II type 2 (AT2) receptor expression was upregulated in confluence-arrested PC12 cells compared with expression in proliferating cells. Treatment with cycloheximide inhibited the increase in mRNA levels in confluent cells. The state of growth arrest by serum deprivation was associated with increased expression of the AT2 receptor, which was markedly suppressed by exposure to the active phorbol ester 12-O-tetradecanoylphorbol 13-acetate and the calcium… CONTINUE READING

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