Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma.

@article{Lee2006RegulationOA,
  title={Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma.},
  author={Terence Kin-Wah Lee and Ronnie Tung-ping Poon and Anthony Yuen and Ming Tat Ling and Xiang Hong Wang and Yong Chuan Wong and Xin-yuan Guan and Kwan Man and Zao You Tang and Sheung Tat Fan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 23},
  pages={6910-9}
}
PURPOSE Metastasis is commonly associated with poor prognosis of hepatocellular carcinoma (HCC). Being an important angiogenic factor, vascular endothelial growth factor (VEGF) plays a central role in HCC growth and metastasis. Recently, Id-1 (inhibitor of differentiation/DNA synthesis) has been suggested to be a key factor in cancer progression but the molecular mechanism remains unknown. EXPERIMENTAL DESIGN We first showed that overexpression of Id-1 was correlated with HCC metastasis (P… CONTINUE READING