Regulation of angiogenesis and matrix remodeling by localized, matrix-mediated antisense gene delivery.

Implantation of biomaterials, such as glucose sensors, leads to the formation of a poorly vascularized collagenous capsule that can lead to implant failure. This process, known as the foreign body reaction (FBR), develops in response to almost all biomaterials and consists of overlapping phases similar to those in wound healing. Implantation of porous… CONTINUE READING