Regulation of androgen receptor activity by tyrosine phosphorylation.

  title={Regulation of androgen receptor activity by tyrosine phosphorylation.},
  author={Zhiyong Guo and Bojie Dai and Tianyun Jiang and Kexin Xu and Yingqiu Xie and Oekyung Kim and Issa Nesheiwat and Xiangtian Kong and Jonathan Melamed and Venkatesh D. Handratta and Vincent C. O. Njar and Angela M. H. Brodie and Li-Rong Yu and Timothy D. Veenstra and Hegang Chen and Yun Qiu},
  journal={Cancer cell},
  volume={10 4},
The androgen receptor (AR) is essential for the growth of prostate cancer cells. Here, we report that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Mutation of the major tyrosine phosphorylation site in AR significantly inhibits the growth of prostate cancer cells under androgen-depleted conditions. The Src tyrosine kinase appears to be responsible for phosphorylating AR, and there is a positive correlation of AR tyrosine… CONTINUE READING
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