Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts.

@article{Inatomi2006RegulationOA,
  title={Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts.},
  author={Osamu Inatomi and Akira Andoh and Yuhki Yagi and Shigeki Bamba and Tomoyuki Tsujikawa and Yoshihide Fujiyama},
  journal={International journal of molecular medicine},
  year={2006},
  volume={18 3},
  pages={497-503}
}
Amphiregulin and epiregulin belong to the epidermal growth factor (EGF) family, and act as mitogenic stimulators via binding to EGF receptors (EGFRs). Amphiregulin and epiregulin are thought to play a role in regenerative responses in the gastrointestinal tract. In this study, we investigated secretion of amphiregulin and epiregulin in human colonic subepithelial myofibroblasts (SEMFs). The mRNA expression and protein secretion of amphiregulin and epiregulin were evaluated by Northern blotting… CONTINUE READING
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