Regulation of amelogenin gene expression during tooth development.

  title={Regulation of amelogenin gene expression during tooth development.},
  author={Esther Chen and Ronald Piddington and Sylvia Decker and Jaehong Park and Z. A. Yuan and William R. Abrams and Joel Rosenbloom and Gerald Feldman and Carolyn Winters Gibson},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={199 3},
The amelogenins are the predominant matrix proteins in developing enamel and are crucial for proper enamel mineralization. Transgenic mice were constructed in order to identify the segment of the amelogenin gene required for specific expression in enamel organ cells. A 3.5 kb fragment of the bovine X-chromosomal amelogenin gene that includes a TATA box, the transcription initiation site, and 32 bp of exon 1 was linked to the beta galactosidase gene and injected into fertilized mouse eggs… CONTINUE READING

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