Regulation of alveolar epithelial function by hypoxia.

@article{Zhou2008RegulationOA,
  title={Regulation of alveolar epithelial function by hypoxia.},
  author={Gongfu Zhou and Laura A Dada and Jacob I Sznajder},
  journal={The European respiratory journal},
  year={2008},
  volume={31 5},
  pages={1107-13}
}
Patients with acute respiratory distress syndrome and high-altitude pulmonary oedema build up excess lung fluid, which leads to alveolar hypoxia. In patients with acute respiratory distress syndrome and hypoxia, there is a decrease in oedema fluid clearance, due in part to the downregulation of plasma membrane sodium-potassium adenosine triphosphatase (Na,K-ATPase). In alveolar epithelial cells, acute hypoxia promotes Na,K-ATPase endocytosis from the plasma membrane to intracellular… CONTINUE READING

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