Regulation of alternative splicing of NMDAR1 in the kindling model.

  title={Regulation of alternative splicing of NMDAR1 in the kindling model.},
  author={John E. Kraus and J. Victor Nadler and James O. McNamara},
  journal={Brain research. Molecular brain research},
  volume={41 1-2},
Kindling refers to a phenomenon in which repeated application of initially subconvulsive electrical stimulations produces limbic and clonic motor seizures of progressively increasing severity. Once established, the increased excitability is lifelong. Several lines of investigation suggest that the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor participates in the expression of the increased neuronal excitability of the kindled brain. Many studies demonstrate that kindling results in… CONTINUE READING