Regulation of aldosterone secretion by the renin-angiotensin system during sodium restriction in rats.

@article{Aguilera1978RegulationOA,
  title={Regulation of aldosterone secretion by the renin-angiotensin system during sodium restriction in rats.},
  author={Greti Aguilera and Kevin J. Catt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 8},
  pages={4057-61}
}
The role of angiotensin II as mediator of the aldosterone response to short periods of sodium restriction was studied in rats by administration of a converting enzyme inhibitor to block formation of the octapeptide throughout the duration of decreased sodium intake. In control animals, short-term sodium restriction caused increased levels of adrenal receptors for angiotensin II, with enhancement of early and late steps in aldosterone biosynthesis and elevation of plasma aldosterone… CONTINUE READING

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