Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.

@article{Nassar2010RegulationOA,
  title={Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.},
  author={Taher Nassar and Serge V. Yarovoi and Rami Abu Fanne and Sa'ed Akkawi and Mahmud Jammal and Timothy Craig Allen and Steven Idell and Douglas B Cines and Abd Al-Roof Higazi},
  journal={American journal of respiratory cell and molecular biology},
  year={2010},
  volume={43 6},
  pages={
          703-11
        }
}
Reactive airway disease is mediated by smooth muscle contraction initiated through several agonist-dependent pathways. Activation of type 1 N-methyl-D-aspartate receptors (NMDA-R1s) by plasminogen activators (PAs) has been linked to control of vascular tone, but their effect on airway smooth muscle contractility has not previously been studied to our knowledge. We observed that NMDA-R1s are expressed by human airway smooth muscle cells and constitutively inhibit the contraction of isolated rat… CONTINUE READING
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