Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production. A mass analysis.

@article{Rubin1991RegulationOA,
  title={Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production. A mass analysis.},
  author={David Rubin and Michael Laposata},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 35},
  pages={
          23618-23
        }
}
Prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2), derived by enzymatic oxidation of cellular dihomogammalinolenic acid (DHLA) and arachidonic acid (AA), respectively, have diverse and, at times, distinct biological actions. It has been suggested that PGE1 specifically inhibits a variety of inflammatory processes, and, in light of the potential therapeutic benefit of PGE1 and its fatty acid precursor in inflammatory disorders, there is growing interest in the biochemical mechanisms which… CONTINUE READING

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