Regulation of adverse remodelling by osteopontin in a genetic heart failure model.

Abstract

AIMS Desmin, the muscle-specific intermediate filament protein, is a major target in dilated cardiomyopathy and heart failure in humans and mice. The hallmarks of desmin-deficient (des(-/-)) mice pathology include pronounced myocardial degeneration, extended fibrosis, and osteopontin (OPN) overexpression. We sought to identify the molecular and cellular… (More)
DOI: 10.1093/eurheartj/ehr119

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