Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease.

@article{Yamagishi2009RegulationOA,
  title={Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease.},
  author={Sho-ichi Yamagishi and Kazuo Nakamura and Takanori Matsui},
  journal={Pharmacological research},
  year={2009},
  volume={60 3},
  pages={174-8}
}
Non-enzymatic modification of proteins by reducing sugars leads to the formation of advanced glycation end products (AGEs), whose process has been reported to progress under physiological aging, oxidative stress or diabetic conditions. There is a growing body of evidence that AGEs and their receptor (RAGE) axis is involved in the pathogenesis of cardiovascular disease (CVD). Indeed, engagement of RAGE with AGEs is shown to elicit oxidative stress generation and subsequently evoke inflammatory… CONTINUE READING
27 Citations
73 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Fat andbeyond : thediversebiologyofPPARgamma

  • A Zinn, S Felson, E Fisher, A Schwartzbard
  • Annu Rev Biochem
  • 2008

PPARgamma agonists and coronary atherosclerosis

  • C Giaginis, Theocharis Tsourouflis G
  • Curr Atheroscler Rep
  • 2008

Similar Papers

Loading similar papers…