Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction.

  title={Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction.},
  author={Masanori Sakaguchi and Yoichi Imaizumi and Tetsuro Shingo and Hirobumi Tada and Ko Hayama and O. Yamada and Tsuyoshi Morishita and Toshihiko Kadoya and Noboru Uchiyama and Takuya Shimazaki and Atsushi Kuno and Françoise Poirier and Jun Hirabayashi and Kazunobu Sawamoto and Hideyuki Okano},
  journal={Journal of neurochemistry},
  volume={113 6},
Neural stem cells (NSCs) proliferate and generate new neurons in the adult brain. A carbohydrate-binding protein (lectin), Galectin-1, is expressed in the NSCs in the subependymal zone (SEZ) of the adult mouse brain. The infusion and knockout of Galectin-1 in the SEZ results in an increase and decrease, respectively, of NSCs and subsequently born progenitor cells. The molecular mechanism of this effect, however, has been unknown. Previous studies outside the brain suggest that Galectin-1 binds… CONTINUE READING

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