Regulation of adult human mesenchymal stem cells into osteogenic and chondrogenic lineages by different bioreactor systems.

@article{Wang2009RegulationOA,
  title={Regulation of adult human mesenchymal stem cells into osteogenic and chondrogenic lineages by different bioreactor systems.},
  author={Tzu-Wei Wang and Hsi-Chin Wu and Hsin-Yen Wang and Feng-huei Lin and Jui-Sheng Sun},
  journal={Journal of biomedical materials research. Part A},
  year={2009},
  volume={88 4},
  pages={
          935-46
        }
}
The aim of this study was to examine the feasibility of expanding and regulating mesenchymal stem cells (MSCs) from isolated adult human bone marrow mononuclear cells, seeded on gelatin-hyaluronic acid biomatrices, and then to quantitatively compare the gene expression in three different culture systems. Individual and interactive effects of model system parameters on construct structure, function, and molecular properties were evaluated. The results showed that these adult human MSCs even at… CONTINUE READING

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