Regulation of adrenomedullin expression and release.

  title={Regulation of adrenomedullin expression and release.},
  author={Naoto Minamino and Katsuro Kikumoto and Yoshitaka Isumi},
  journal={Microscopy research and technique},
  volume={57 1},
Adrenomedullin (AM) was originally identified in the extracts of human pheochromocytoma tissue, but this peptide is now known to be synthesized and secreted from many kinds of cells in the body, including vascular smooth muscle cells, endothelial cells, fibroblasts, cardiac myocytes, epithelial cells, and cancer cells. In this review, we summarize AM-secreting and AM gene-expressing cells in addition to the regulation of secretion and gene expression of AM. Although the data are still limited… CONTINUE READING