Regulation of adrenal and ovarian steroidogenesis by miR-132.

  title={Regulation of adrenal and ovarian steroidogenesis by miR-132.},
  author={Zhigang Hu and Wen-Jun Shen and Fredric B Kraemer and Salman Azhar},
  journal={Journal of molecular endocrinology},
  volume={59 3},
miR-132 is hormonally regulated in steroidogenic cells of the adrenal gland, ovary and testis. Here, we examined the potential role of miR-132 in the control of steroidogenesis. Transfection of Y1 adrenal cells with miR-132 increased mRNAs of 3β-HSD and 20α-HSD enzymes, which catalyze the sequential conversion of pregnenolone to progesterone to biologically inactive 20α-hydroxyprogesterone (20α-OHP). Overexpression of miR-132 reduced MeCP2 and StAR protein expression, basal progestin… CONTINUE READING