Regulation of adipose triglyceride lipase by rosiglitazone.

  title={Regulation of adipose triglyceride lipase by rosiglitazone.},
  author={L-F Liu and Aparna Purushotham and Angela A. Wendel and Kazunori Koba and Jeffrey A Deiuliis and K Lee and Martha A. Belury},
  journal={Diabetes, obesity & metabolism},
  volume={11 2},
AIM To elucidate the mechanism by which rosiglitazone regulates adipose triglyceride lipase (ATGL). METHODS Male C57Bl/6 mice were treated with rosiglitazone daily (10 mg/kg body weight), and adipose tissues were weighed and preserved for mRNA and protein analysis of ATGL. In parallel, preadipocyte (3T3-L1) cells were differentiated with insulin/dexamethasone/3-isobutyl-1-methlxanthine cocktail or rosiglitazone, and ATGL levels were measured with real-time PCR, western blotting and… CONTINUE READING
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