Regulation of adipogenesis by natural and synthetic REV-ERB ligands.

  title={Regulation of adipogenesis by natural and synthetic REV-ERB ligands.},
  author={Naresh Kumar and Laura A Solt and Yongjun Wang and Pamela M. Rogers and Gargi Bhattacharyya and Theodore M Kamenecka and Keith R. Stayrook and Christine Crumbley and Z Elizabeth Floyd and Jeffrey M. Gimble and Patrick R. Griffin and Thomas P Burris},
  volume={151 7},
The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbalpha expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for REV-ERB, and binding of heme is required for the receptor's activity. We therefore hypothesized that REV-ERB ligands may play a role in regulation of adipogenesis. We detected an increase… CONTINUE READING


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