Regulation of adipocyte lipolysis

  title={Regulation of adipocyte lipolysis},
  author={Gema Fr{\"u}hbeck and Leire M{\'e}ndez-Gim{\'e}nez and Jose A Fern{\'a}ndez-Formoso and Secundino Fern{\'a}ndez and Amaia Rodr{\'i}guez},
  journal={Nutrition Research Reviews},
  pages={63 - 93}
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation are the best known. Initially, hormone-sensitive lipase (HSL) was thought to be the rate-limiting enzyme of the first lipolytic step, while we now… 
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics.
The understanding of adipocyte lipolysis has greatly increased over the past 50 years from a basic enzymatic process to a dynamic regulatory one, involving the assembly and disassembly of protein complexes on the surface of LDs.
Cardiotrophin-1 stimulates lipolysis through the regulation of main adipose tissue lipases[S]
The ability ofCT-1 to regulate the activity of the main lipases underlies the lipolytic action of this cytokine in vitro and in vivo, and could contribute to CT-1 antiobesity effects.
Hypoxia-Inducible Lipid Droplet–Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue
The data do not support an important direct role of HILPDA in the regulation of lipolysis in adipocytes in vivo and in vitro, and it is found that HilPDA is highly abundant in adipose tissue, where its levels are induced by peroxisome proliferator-activated receptor γ and β-adrenergic stimulation.
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
It is suggested that phosphorylation of PDE3B by Akt is not required for insulin to suppress adipocyte lipolysis, and a mutant form of Pde3b that ablates the major Akt phosphorylated site, murine S273, is restored.
Effects of AMPK activation on lipolysis in primary rat adipocytes: studies at different glucose concentrations
Results indicate that short-term activation of AMPK by AICAR in the rat adipocytes inhibits lipolysis, due to changes in the final, followed by protein kinase A (PKA), steps of the lipolytic cascade and improves intracellular energy status.
Oncostatin M promotes lipolysis in white adipocytes
OSM signalling directly promotes lipolysis in white adipocytes in an ERK1/2-dependent manner, and is shown to inhibit adipogenesis, suppress browning, and contribute to insulin resistance in cultured white adipocyte cell line.
Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting
A regulatory transcriptional program in rat epididymal (EPI) adipose tissue favoring lipolysis during phase 2 and repressing it during phase 3 is reported, and the mRNA and circulating levels of adipose-secreted factors were consistent with the repression of insulin signaling during prolonged fasting.
Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial
LPS stimulated lipolysis in adipose tissue and is associated with increased pHSL and signs of increased PLIN1 phosphorylation combined with a trend toward decreased insulin signaling, and the combination of these mechanisms appear to be the driving forces behind the increasedlipolysis observed in the early stages of acute inflammation and sepsis.
Peroxisomal-PEX5 Controls Fasting-Induced Lipolysis
The results show that PEX5 plays a pivotal role in PKA induced lipolysis that occurs upon nutritional deprivation, and speculate that the contact between LDs and peroxisomes could facilitate lipid metabolism via exchange of lipid metabolites between the organelles in response to nutritional changes.


Lipolysis and lipid mobilization in human adipose tissue.
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
Intricate cooperation of these endocrine and autocrine/paracrine factors leads to a fine regulation of lipolysis in adipocytes, needed for energy homeostasis.
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis
This review will focus on adipocyte lipolysis with emphasis on hormone signal transduction, lipolytic enzymes, the lipid storage droplet, and fatty acid release from the adipocyte.
Regulation of lipolysis in adipocytes.
This review provides an overview of key mediators of lipolysis and the regulation of this process by changes in nutritional status and nutrient intakes.
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
  • C. Holm
  • Biology
    Biochemical Society transactions
  • 2003
Basal hyperinsulinaemia, release of exaggerated amounts of insulin during glucose challenges and retarded glucose disposal during insulin tolerance tests suggest that HSL-null mice are insulin resistant, suggesting the presence of additional, although not necessarily hormone-activatable, triacylglycerol lipase(s).
Signalling mechanisms regulating lipolysis.
Millennium fat-cell lipolysis reveals unsuspected novel tracks.
Genetic studies show that beta2-adrenoceptor and hormone-sensitive lipase genes may participate in the polygenic background of obesity, and a novel lipolytic system has been characterized in human fat cells.
Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes*
Investigation of the roles of HSL, ATGL, and its coactivator CGI-58 in basal and forskolin-stimulated lipolysis in a human white adipocyte model, the hMADS cells suggest that ATGL/CGI-58 acts independently of H SL and precedes its action in the sequential hydrolysis of triglycerides in human hM ADS adipocytes.
Human fat cell lipolysis: biochemistry, regulation and clinical role.
  • P. Arner
  • Biology, Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2005
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
lipolysis is mediated not only by HSL but also by the non-HSL TG lipase, whose responses to lipolytic hormones are similar to those of HSL, and it is proposed that both lipases are regulated by common mechanism of lipolysis.