Regulation of adenylate cyclase from cultured human cell lines by adenosine.

  title={Regulation of adenylate cyclase from cultured human cell lines by adenosine.},
  author={Richard B. Clark and Megan Seney},
  journal={The Journal of biological chemistry},
  volume={251 14},
  • R. ClarkM. Seney
  • Published 25 July 1976
  • Biology
  • The Journal of biological chemistry

Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells

It is reported here that the inhibition by adenosine of the increase in the intracellular level of cyclic AMP evoked by isoprenaline in cultured glioblasts is mediated by extracellular receptors.

Regulation of adenylate cyclase by adenosine

A unitary model is proposed which explains both the stimulatory and inhibitory effects of low concentrations of adenosine on adenylate cyclase as well as the effects of methyl xanthines on cyclic AMPs in many tissues.

Adenosine interactions with thyroid adenylate cyclase.

Effect of adenosine and adenosine 5'-monophosphate on cell division of cultured mastocytoma P-815 cells.

AMP inhibits the growth of mouse mastocytoma P-815 cells as a result of its continuous conversion to adenosine and a constant exposure of the cells to a low concentration ofAdenosine which readily permeates the cell membrane, and also acts extracellularly for growth inhibition by regulating cAMP levels.

Coupling of a single adenylate cyclase to two receptors: adenosine and catecholamine.

It is concluded that the two ligands, adenosine and the beta-agonist, activate the adenylate cyclase through a common guanyl nucleotide regulatory site, supported by the finding that both adenosines and 1-epinephrine induce the reversal of the permanently active state, irrespective by which pathway the enzyme was activated.


Naunyns- Schmiedeberg’s Arch. Pharmacol

  • Endocrinology
  • 1974