Regulation of adenosine levels during cerebral ischemia

  title={Regulation of adenosine levels during cerebral ischemia},
  author={Stephanie C. Chu and Wei Xiong and Dali Zhang and Hanifi Soylu and Chao Sun and B. C. Albensi and Fiona E Parkinson},
  booktitle={Acta Pharmacologica Sinica},
Adenosine is a neuromodulator with its level increasing up to 100-fold during ischemic events, and attenuates the excitotoxic neuronal injury. Adenosine is produced both intracellularly and extracellularly, and nucleoside transport proteins transfer adenosine across plasma membranes. Adenosine levels and receptor-mediated effects of adenosine are regulated by intracellular ATP consumption, cellular release of ATP, metabolism of extracellular ATP (and other adenine nucleotides), adenosine influx… CONTINUE READING


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