Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: desensitization to catecholamines and prostaglandins.

Abstract

Human astrocytoma cells (1321N1) exhibit adenylate cyclase activities coupled to independent receptors for catecholamines and prostaglandins of the E-series. Exposure of the cells to either norepinephrine or prostaglandin E1 (PGE1) results in an initial rapid accumulation of cyclic AMP but also results in a progressive loss of responsiveness of the cells to… (More)

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@article{Su1976RegulationOA, title={Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: desensitization to catecholamines and prostaglandins.}, author={Yin Su and Luis Cubeddu and John P. Perkins}, journal={Journal of cyclic nucleotide research}, year={1976}, volume={2 4}, pages={257-70} }