Regulation of acute graft-versus-host disease by microRNA-155.

  title={Regulation of acute graft-versus-host disease by microRNA-155.},
  author={Parvathi Ranganathan and Catherine E A Heaphy and Stefan Costinean and Nicole M Stauffer and Caroline Na and Mehdi Hamadani and Ramasamy Santhanam and Charlene Mao and Patricia A. Taylor and Sukhinder K. Sandhu and Gang He and Arwa Y. Shana'ah and Gerard J Nuovo and Alessandro Lagan{\`a} and Luciano Cascione and Susanna Obad and Oliver Jay Broom and Sakari Kauppinen and John C. Byrd and Michael A. Caligiuri and Danilo Perrotti and Gregg A. Hadley and Guido Marcucci and Steven Michael Devine and Bruce R Blazar and Carlo M. Croce and Ramiro Garzon},
  volume={119 20},
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we hypothesized that miR-155 is involved in the modulation of aGVHD. Here we show that miR-155 expression was up-regulated in T cells from mice developing aGVHD after alloHSCT. Mice… CONTINUE READING