Regulation of activation induced deaminase via phosphorylation.

  title={Regulation of activation induced deaminase via phosphorylation.},
  author={Uttiya Basu and Jayanta Chaudhuri and Ryan T. Phan and Abhishek Datta and Frederick W Alt},
  journal={Advances in experimental medicine and biology},
Immunoglobulin gene diversification by somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion is dependent upon activation-induced cytidine deaminase (AID). AID is a single-stranded DNA specific cytidine deaminase that is expressed primarily in activated mature B lymphocytes. AID appears to catalyze DNA cytidine deamination of immunoglobulin heavy (IgH) and light chain (IgL) variable region (V) exons and IgH switch (S) region sequences to initiate, respectively, IgH… CONTINUE READING