Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.

@article{Basu2009RegulationOA,
  title={Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.},
  author={Uttiya Basu and Andrew Franklin and Bjoern Schwer and H J Cheng and Jayanta Chaudhuri and Frederick W Alt},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 3},
  pages={561-8}
}
Human and mouse Ig genes are diversified in mature B-cells by distinct processes known as Ig heavy-chain CSR (class switch recombination) and Ig variable-region exon SHM (somatic hypermutation). These DNA-modification processes are initiated by AID (activation-induced cytidine deaminase), a DNA cytidine deaminase predominantly expressed in activated B-cells… CONTINUE READING