Regulation of activation-induced cell death of mature T-lymphocyte populations

@article{Janssen2000RegulationOA,
  title={Regulation of activation-induced cell death of mature T-lymphocyte populations},
  author={Ottmar Janssen and Ralf Sanzenbacher and Dieter Kabelitz},
  journal={Cell and Tissue Research},
  year={2000},
  volume={301},
  pages={85-99}
}
Abstract Resting mature T lymphocytes are activated when triggered via their antigen-specific T-cell receptor (TCR) to elicit an appropriate immune response. In contrast, preactivated T cells may undergo activation-induced cell death (AICD) in response to the same signals. Along with cell death induced by growth factor deprivation, AICD followed by the elimination of useless or potentially harmful cells preserves homeostasis, leads to the termination of cellular immune responses and ensures… CONTINUE READING
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