Regulation of actin polymerization by villin, a 95,000 dalton cytoskeletal component of intestinal brush borders.

@article{Craig1980RegulationOA,
  title={Regulation of actin polymerization by villin, a 95,000 dalton cytoskeletal component of intestinal brush borders.},
  author={Susan W. Craig and Leland D. Powell},
  journal={Cell},
  year={1980},
  volume={22 3},
  pages={739-46}
}
A 95,000 dalton actin-binding polypeptide, villin, has been purified to 98% homogeneity from brush border cytoskeletons of chicken intestinal epithelial cells. In vitro, this protein exerts control over the polymerization of actin. In the presence of villin, the lag phase preceding detectable actin polymerization is shortened and the steady state equilibrium viscosity is reduced in proportion to the amount of villin present. A molar ratio of villin:actin of 1:40 results in a 70% reduction of… CONTINUE READING
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