Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.

@article{Nadella2009RegulationOA,
  title={Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.},
  author={Kiran S Nadella and Motoyasu Saji and Naduparambil Korah Jacob and Emilia Pavel and Matthew D. Ringel and Lawrence S. Kirschner},
  journal={EMBO reports},
  year={2009},
  volume={10 6},
  pages={599-605}
}
Proper regulation of the cAMP-dependent protein kinase (protein kinase A, PKA) is necessary for cellular homeostasis, and dysregulation of this kinase is crucial in human disease. Mouse embryonic fibroblasts (MEFs) lacking the PKA regulatory subunit Prkar1a show altered cell morphology and enhanced migration. At the molecular level, these cells showed increased phosphorylation of cofilin, a crucial modulator of actin dynamics, and these changes could be mimicked by stimulating the activity of… CONTINUE READING
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